Stark racial and ethnic disparities in Alzheimer’s disease (AD) and related dementias (ADRD) have been documented, largely attributable to the impact of social and structural drivers of health. The structural drivers of health include the institutions, practices, cultural norms, and policies that dictate the inequitable distribution of the social determinants of health (SDoH), defined as the conditions where people live, work, play, and age, and consist of various forms of systemic oppression including structural racism. The overlapping effects of race and place on health have been studied extensively, with an increased focus on the operationalization and measurement of “place-effects” on health through neighborhood characteristics and the built environment. Previous studies have demonstrated associations of place-based SDoH with cardiometabolic health and cognition. However, research studying the relationship of place-based SDoH with ADRD-associated neuroimaging and plasma biomarkers is still limited.